Is heart rate reduction more important than target dose in chronic heart failure therapy with a beta-blocker?
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چکیده
منابع مشابه
Is heart rate reduction more important than target dose in chronic heart failure therapy with a beta-blocker?
Beta-adrenoceptor blocking agents (beta-blockers) are now well established as cornerstone therapy in patients with systolic chronic heart failure (CHF). Clinical data have overwhelmingly proven the beneficial effects of beta-blocker therapy in terms of improving patient prognosis, decreasing requirements for hospitalization, and postponing disease progression. However, it remains unclear what t...
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In a double-blind randomised placebo-controlled trial including about 6500 heart failure patients, ivabradine did not reduce overall mortality or cardiovascular mortality. Ivabradine reduced mortality due to heart failure, but not in the subgroup of patients receiving at least half the recommended dose of a beta-blocker. In a double-blind randomised placebo-controlled trial in about 10 000 pati...
متن کاملProphylactic pacemaker use to allow beta-blocker therapy in patients with chronic heart failure with bradycardia
Health technology The study compared two treatment strategies for patients with chronic heart failure (CHF). The strategies compared were the conventional strategy and the pacemaker-carvedilol strategy. In the conventional strategy, patients were treated with angiotensin-converting enzyme inhibitors, diuretics and digoxin. In the pacemaker-carvedilol strategy, patients received conventional tre...
متن کاملProphylactic pacemaker use to allow beta-blocker therapy in patients with chronic heart failure with bradycardia.
BACKGROUND Although the benefits of beta-blocker therapy for patients with congestive heart failure (CHF) are independent of pretreatment heart rate, patients with chronic systolic heart failure and low resting heart rates are often excluded from beta-blocker therapy. We investigated the effectiveness and cost-effectiveness of prophylactic pacemaker insertion to facilitate beta-blocker use in t...
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The use of β-blockers (BB) in heart failure (HF) has been considered a contradiction for many years. Considering HF simply as a state of inadequate systolic function, BB were contraindicated because of their negative effects on myocardial contractility. Nevertheless, evidence collected in the past years have suggested that additional mechanisms, such as compensatory neuro-humoral hyperactivatio...
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ژورنال
عنوان ژورنال: Journal of Geriatric Cardiology
سال: 2012
ISSN: 1671-5411
DOI: 10.3724/sp.j.1263.2011.00260